A portable protein nanopore
نویسندگان
چکیده
منابع مشابه
Erratum: A reference bacterial genome dataset generated on the MinIONTM portable single-molecule nanopore sequencer
[This corrects the article DOI: 10.1186/2047-217X-3-22.].
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BACKGROUND The MinION™ is a new, portable single-molecule sequencer developed by Oxford Nanopore Technologies. It measures four inches in length and is powered from the USB 3.0 port of a laptop computer. The MinION™ measures the change in current resulting from DNA strands interacting with a charged protein nanopore. These measurements can then be used to deduce the underlying nucleotide sequen...
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Protein sequences are recoded with a binary alphabet obtained by dividing the 20 amino acids into two subsets based on volume. A protein is identified from subsequences by database search. Computations on the Helicobacter pylori proteome show that over 93% of binary subsequences of length 20 are correct at a confidence level exceeding 90%. Over 98% of the proteins can be identified, most have m...
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A nanopore immunosensor is demonstrated for peanut protein Ara h1, a common food allergen. This biosensor is constructed by immobilizing the antibody to peanut protein Ara h1 within Au-coated pores of commercial nanoporous polycarbonate membranes. Peanut protein Ara h1 is detected as the change in the pore conductivity as the pores are partially obscured by antigen binding. Control experimentsw...
متن کاملDiscrimination of supramolecular chirality using a protein nanopore.
Supramolecular chirality may emerge from self-assembly processes to yield architectures that differ only in the topological arrangement of their constituent parts. Since the properties of the resulting enantiomeric assemblies are identical, purification and characterisation can be challenging. Here, we have examined the hypothesis that the intrinsic chirality of a protein nanopore can be exploi...
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ژورنال
عنوان ژورنال: Analytical Chemistry
سال: 2007
ISSN: 0003-2700,1520-6882
DOI: 10.1021/ac0719204